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A family history has been found in about one-third of migraineurs.[77,78] A positive family history is associated with more frequent migraine attacks that are severe and of a longer duration, develop more often during the menstrual cycle, and are more severe in women than in men. Cluster headache also may be inherited in an autosomal dominant fashion.[79,80] Mutations of sodium channel beta 1-subunit genes SCN1A, SCN2A, SCN3A, and SCN9A have been implicated in familial episodic atypical headache.[81-84] An association with antibodies to aquaporin-4 has been observed in cluster headache.[85,86]
A variety of comorbid conditions have been documented in patients with cluster headache and other primary headaches, including schizophrenia, anxiety disorders, and other psychiatric illnesses.[87-90] Psychiatric disorders may be a result of the headache rather than a predisposing comorbid condition or the result of a shared genetic predisposition.[91,92] For some patients, TACs symptoms or attacks are associated with a phobic response, which is characterized by physical symptoms that could be considered as a form of ritual purification.[94-96]
TACs are one of a group of primary headaches, the others being classified as having migraine, tension-type, and mixed. Tension-type headaches are further subdivided based on how they may be felt or associated with, including: location throbbing tightness stinging heavy aching thumping aching tightness
The organization of this table is important when talking about the symptoms of headaches. "Symptom" is defined as any physical sensation a the site of symptoms such as headache or jaw pain. Symptoms are distinct events that happen to the patient and can be called "attacks. d2c66b5586
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